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RegisterFirst time lag time [Software]
posted by Helmut 
– Vienna, Austria, 2009-02-02 14:08 (5560 d 15:10 ago) – Posting: # 3172
Views: 8,917
Dear D. Labes!
Oh dear!
Hhm, I didn’t know this paper also. The approach seems reasonably to me.
In PK modeling one would come up with exactly such a value.
I remember a paper by H. Blume dealing with gastric resistant diclofenac, where he used tmax-tlag as a parameter describing the rate (drug dependent) and evaluated tlag separately (formulation dependent).
The collection of Blume/Mutschler (in German, out of print) contains some examples.
❝ Meanwhile I came into touch with the lag time (first in my long, long career in BE studies) in a food BE study for one of the "(in)famous" ...prazoles.
Oh dear!
❝ […] I found the following paper […]
❝
❝ What do you think?
Hhm, I didn’t know this paper also. The approach seems reasonably to me.
In PK modeling one would come up with exactly such a value.
❝ What should be done with this parameter? Reporting the values only (with summary statistics) or any statistical analysis of differences between formulations under study? Which statistical method, model?
I remember a paper by H. Blume dealing with gastric resistant diclofenac, where he used tmax-tlag as a parameter describing the rate (drug dependent) and evaluated tlag separately (formulation dependent).
The collection of Blume/Mutschler (in German, out of print) contains some examples.
Henning Blume, Ernst Mutschler
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Helmut Schütz
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Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- Lag time in WinNonlin - bug or feature? Helmut 2008-05-26 15:26 [Software]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Lag time in WinNonlin - bug or feature? d_labes 2008-05-29 16:47
- WinNonlin <--> Kinetica... / Survey Helmut 2008-05-29 20:03
- Tlag d_labes 2008-05-30 08:12
- First time lag time d_labes 2009-02-02 12:48
- First time lag timeHelmut 2009-02-02 13:08
- lag time paper d_labes 2009-02-02 13:42
- First time lag timeHelmut 2009-02-02 13:08
- Lag time in WinNonlin - bug or feature? SDavis 2009-02-04 12:49
- Lag time in WinNonlin - bug or feature? Helmut 2009-02-04 13:05
- WinNonlin <--> Kinetica... / Survey Helmut 2008-05-29 20:03
- Lag time in WinNonlin - bug or feature? d_labes 2008-05-29 16:47
Ing. Helmut Schütz