## Calculation of AUC0-72 [NCA / SHAM]

Dear D. Labes,

If a value is missing – or even came up as <LOQ in repeated analyses – and is included within values which are clearly (!) above LOQ I routinely substitute such a value by a (log)interpolated estimate. I have such a procedure since decades (oh, I’m getting old) in my protocols, and never got any problems.

This wouldn’t bother me as long as C

Yes.

❝ I am with you if the values in the last part of the concentration time course are <LOQ. But I think it's different with missing values (vial broken or so) especially in case of long half life drugs.

If a value is missing – or even came up as <LOQ in repeated analyses – and is included within values which are clearly (!) above LOQ I routinely substitute such a value by a (log)interpolated estimate. I have such a procedure since decades (oh, I’m getting old) in my protocols, and never got any problems.

❝ Because time points are spread occasionally with 24h in the last part, there may be a considerable portion of AUC missing.

This wouldn’t bother me as long as C

_{last}≥2–4 times t_{max}.❝ ❝ I wouldn’t start trying to get an estimate of C_{72}.

❝

❝ Is this sentence then furthermore your opinion?

Yes.

—

Helmut Schütz

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*Dif-tor heh smusma*🖖🏼 Довге життя Україна!_{}Helmut Schütz

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### Complete thread:

- Calculation of AUC0-72 Sasi 2008-06-10 10:44 [NCA / SHAM]
- Calculation of AUC0-72 Jaime_R 2008-06-10 12:18
- Calculation of AUC0-72 Ohlbe 2008-06-10 17:28
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- Regulators truncated d_labes 2009-06-18 09:26
- Calculation of AUC0-72 d_labes 2008-09-05 15:00
- Calculation of AUC0-72 Helmut 2009-01-26 16:24
- Calculation of AUC0-72 d_labes 2009-01-26 16:57
- Calculation of AUC0-72Helmut 2009-01-26 17:20
- The missing 72h d_labes 2009-01-27 11:48
- The missing 72h Ohlbe 2009-01-28 00:00
- sensitivity analyses ? martin 2009-01-28 08:26
- Regulators ways are inscrutable d_labes 2009-01-28 09:54
- Regulators ways are inscrutable (at least the French) Ohlbe 2009-01-28 10:16

- The missing 72h ElMaestro 2009-01-28 14:32
- Page 3848 of 221 d_labes 2009-01-28 14:51

- Partial AUC calculation Astea 2017-03-11 20:14
- Partial AUC calculation mittyri 2017-03-16 19:46

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- The missing 72h d_labes 2009-01-27 11:48

- Calculation of AUC0-72Helmut 2009-01-26 17:20

- Calculation of AUC0-72 d_labes 2009-01-26 16:57

- Calculation of AUC0-72 Helmut 2009-01-26 16:24

- Calculation of AUC0-72 Jaime_R 2008-06-10 18:45

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