Bioequivalence and Bioavailability Forum • Switchability and Prescribability in WinNonlin

Switchability and Prescribability in WinNonlin [Software]

posted by MGR – India, 2008-12-30 11:12 (5737 d 11:14 ago) – Posting: # 2985
Views: 28,464

Dear Helmut,

In the previous reply, you have given the output of WinNonlin like,

❝ Final variance parameter estimates:

❝ lambda(1,1)_11 0.885348

❝ lambda(1,2)_11 0.922848

❝ lambda(2,2)_11 0.213429

❝ Var(period*treatment*subject)_21 0.224827

❝ Var(period*treatment*subject)_22 0.0853385

But my doubt is that, Can we find the Switchability, Prescribability and Global Variance from the above data in WinNonlin? If so can you please give me the formulas to calculate these parameters? As we are dealing a project of replicate, in the protocol they had mentioned these parameters.

Thanks in advance.

—
Regards,
MGR

Complete thread:

SAS code of partial replicate design pa1kumar.anna 2008-12-01 09:51 [Software]
- Etiquette Ohlbe 2008-12-01 10:45
- SAS code for what? d_labes 2008-12-02 09:17
  - partial replicate = 3-period replicate Helmut 2008-12-03 15:42
    - partial replicate = 3-period replicate MGR 2008-12-04 11:19
    - 3-period replicate designs and SAS d_labes 2008-12-04 14:17
      - Extra-reference or partial replicate design d_labes 2008-12-12 10:51
        
        Extra-reference or partial replicate design Helmut 2008-12-12 11:34
        
        Simple minded d_labes 2008-12-12 13:28
        
        Simple minded Helmut 2008-12-12 14:58
        
        SAS and WinNonlin d_labes 2008-12-12 15:44
        
        SAS and WinNonlin Helmut 2008-12-12 16:33
        
        SAS and WinNonlin BEQool 2024-07-29 09:38
        
        Phoenix RSABE-template Helmut 2024-07-29 13:29
        
        Phoenix RSABE-template BEQool 2024-07-29 19:47
        
        CVw in Phoenix RSABE-template Helmut 2024-07-30 09:15
        
        CVw in Phoenix RSABE-template BEQool 2024-07-30 10:56
        
        CVw in Phoenix RSABE-template and PowerTOST CI2CV() Helmut 2024-07-30 11:23
        
        CVw in Phoenix RSABE-template and PowerTOST CI2CV() BEQool 2024-07-31 05:49
        
        General ABE? mittyri 2024-07-31 18:25
        
        General ABE? BEQool 2024-08-01 05:45
        
        Switchability and Prescribability in WinNonlinMGR 2008-12-30 10:12
        
        PBE and IBE in WinNonlin Helmut 2008-12-30 16:04
        
        PBE and IBE in WinNonlin MGR 2008-12-31 07:52
        
        Switchability NPavan 2009-01-12 13:10