Bioequivalence and Bioavailability Forum • Risperidone Cross-over design query

Risperidone Cross-over design query [Design Issues]

posted by ElMaestro – Denmark, 2008-12-25 08:41 (6397 d 08:32 ago) – Posting: # 2977
Views: 5,813

Since you are comparing fomulations and not metabolisms, I think it would be acceptable (in a purely scientific manner) to simply write in the protocol that poor metabolisers are excluded; this involves testing for it at the time of recruitment.
Then it becomes easier to time the blood sampling and shorten the study/period duration.

EM.

Complete thread:

Risperidone Cross-over design query Rahul 2008-12-24 06:11 [Design Issues]
- Risperidone Cross-over design query raghu 2008-12-24 13:00
  - Risperidone Cross-over design queryElMaestro 2008-12-25 07:41
    - Risperidone and its metabolite kvgreddy06 2014-04-23 09:19
- Pheno-/genotyping Helmut 2008-12-25 13:44