Bioequivalence and Bioavailability Forum

Dear Shinmar & Jo!

❝ CV (coefficient of variation) is a constant used to define variability, based on standard deviation, in data without considering any effect.

Not a constant, but an estimate.
Therefore one should consider its uncertainty (dependent on the sample size) if applying the number in further study planning.

❝ [...] as it is clear from the following formula:

❝ Inter-subject CV = 100 x (MSSubject (Seq) - MSResidual/2)^0.5

Nice, but your formula is valid only for untransformed data (additive model).
For formulas of the multiplicative model (log-transformed data) of most PK metrics see this post.