SAS and WinNonlin [Software]

posted by Helmut Homepage – Vienna, Austria, 2008-12-12 17:33 (5899 d 20:21 ago) – Posting: # 2919
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Dear D. Labes,

thanks for SAS' output!

❝ Seems 'Method of moments' is used here?


Yes – but only to get initial variance estimates.

❝ With the exception of lambda(1,1) there seems no match :-( !


Yes. :confused:

❝ Now we need someone with knowledge of relationship of SAS and WINNONLIN parameters.


We should wait for Simon Davis coming by (he has also experience with SAS)...

❝ Is var(period*treatment*subject) the intra-subject variability?


Yes, well the variance (and you get the CV in the usual way; not built-in in WinNonlin: pocket-calculator business):
Var(period*treatment*subject)_21 sigma²reference
Var(period*treatment*subject)_22 sigma²test

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