Bioequivalence and Bioavailability Forum

SAS and WinNonlin [Software]

posted by d_labes  – Berlin, Germany, 2008-12-12 16:44 (5899 d 21:52 ago) – Posting: # 2918
Views: 30,596

Dear Helmut,

thanks for your very quick replay.

❝ I fitted C_max with your modified sequences (because I didn't want to start with incomplete AUC data) in WinNonlin to PBE/IBE and obtained:

❝ SigmaR  0.9999185

❝ SigmaWR 0.4480995 (no SigmaWT!)

Seems 'Method of moments' is used here?

❝ If I run ABE in WinNonlin I'm lost in the options; choosing the defaults [...]

❝ I get

❝ Final variance parameter estimates:

❝            lambda(1,1)_11         0.885348

❝            lambda(1,2)_11         0.922848

❝            lambda(2,2)_11         0.213429

❝ Var(period*treatment*subject)_21  0.224827

❝ Var(period*treatment*subject)_22  0.0853385

Here are the covariance parameters from Proc MIXED (FDA code)

                        Covariance Parameter Estimates

  Cov Parm   Subject   Group          Estimate   Alpha     Lower     Upper

  FA(1,1)    subject                    0.8865     0.1    0.7644    1.0425
  FA(2,1)    subject                    0.9554     0.1    0.8036    1.1073
  FA(2,2)    subject                  3.06E-17       .         .         .
  Residual   subject   treatment R      0.1931     0.1    0.1500    0.2597
  Residual   subject   treatment T      0.1277     0.1    0.07846   0.2518

With the exception of lambda(1,1) there seems no match !
Now we need someone with knowledge of relationship of SAS and WINNONLIN parameters.
Is var(period*treatment*subject) the intra-subject variability?

But enough to now. Have a nice weekend.

Complete thread:

• SAS code of partial replicate design pa1kumar.anna 2008-12-01 09:51 [Software] 
  • Etiquette Ohlbe 2008-12-01 10:45
  • SAS code for what? d_labes 2008-12-02 09:17
    • partial replicate = 3-period replicate Helmut 2008-12-03 15:42
      • partial replicate = 3-period replicate MGR 2008-12-04 11:19
      • 3-period replicate designs and SAS d_labes 2008-12-04 14:17
        • Extra-reference or partial replicate design d_labes 2008-12-12 10:51
          • Extra-reference or partial replicate design Helmut 2008-12-12 11:34
            • Simple minded d_labes 2008-12-12 13:28
              • Simple minded Helmut 2008-12-12 14:58
                • SAS and WinNonlind_labes 2008-12-12 15:44
                  • SAS and WinNonlin Helmut 2008-12-12 16:33
                    • SAS and WinNonlin BEQool 2024-07-29 09:38
                      • Phoenix RSABE-template Helmut 2024-07-29 13:29
                        • Phoenix RSABE-template BEQool 2024-07-29 19:47
                          • CVw in Phoenix RSABE-template Helmut 2024-07-30 09:15
                            • CVw in Phoenix RSABE-template BEQool 2024-07-30 10:56
                              • CVw in Phoenix RSABE-template and Power­TOST CI2CV() Helmut 2024-07-30 11:23
                                • CVw in Phoenix RSABE-template and Power­TOST CI2CV() BEQool 2024-07-31 05:49
                                  • General ABE? mittyri 2024-07-31 18:25
                                    • General ABE? BEQool 2024-08-01 05:45
                • Switchability and Prescribability in WinNonlin MGR 2008-12-30 10:12
                  • PBE and IBE in WinNonlin Helmut 2008-12-30 16:04
                    • PBE and IBE in WinNonlin MGR 2008-12-31 07:52
                      • Switchability NPavan 2009-01-12 13:10