Bioequivalence and Bioavailability Forum • Simple minded

Simple minded [Software]

posted by Helmut – Vienna, Austria, 2008-12-12 15:58 (5759 d 19:08 ago) – Posting: # 2916
Views: 28,907

Dear D. Labes,

❝ I guess this is not a problem of SAS. It may be a problem of what we (I) do with it. Fitting an inappropriate? or over-specified? model.

❝

❝ Eventually anybody can fit the underlying model in WINNONLIN or R using REML to see what happens?

❝ I place a bet that then also a fitted value for s²_WT is obtained :-P . Maybe it is even correct!?

I fitted C_max with your modified sequences (because I didn't want to start with incomplete AUC data) in WinNonlin to PBE/IBE and obtained:

SigmaR  0.9999185

SigmaWR 0.4480995

(no SigmaWT!)

❝ (I confabulate: total variability of T: estimable; variability of T-R: estimable and sum of intra-subject variabilities + treatment*subject interaction; intra-subject variability of R: estimable; so ......)

If I run ABE in WinNonlin I'm lost in the options; choosing the defaults (no time to dig into the manual right now...)

fixed:    sequence+treatment+period

random:   subject(treatment) Type: Banded No-Diagonal Factor Analytic(f=2)

repeated: subject(period)   Group: treatment Type: Variance components

I get

Final variance parameter estimates:

           lambda(1,1)_11         0.885348

           lambda(1,2)_11         0.922848

           lambda(2,2)_11         0.213429

Var(period*treatment*subject)_21  0.224827

Var(period*treatment*subject)_22  0.0853385

where according to this post lambda(1,1)_11, lambda(1,2)_11 and lambda(2,2)_11 correspond to SAS' FA(1,1), FA(2,1) and FA(2,2)...

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz

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Complete thread:

SAS code of partial replicate design pa1kumar.anna 2008-12-01 09:51 [Software]
- Etiquette Ohlbe 2008-12-01 10:45
- SAS code for what? d_labes 2008-12-02 09:17
  - partial replicate = 3-period replicate Helmut 2008-12-03 15:42
    - partial replicate = 3-period replicate MGR 2008-12-04 11:19
    - 3-period replicate designs and SAS d_labes 2008-12-04 14:17
      - Extra-reference or partial replicate design d_labes 2008-12-12 10:51
        
        Extra-reference or partial replicate design Helmut 2008-12-12 11:34
        
        Simple minded d_labes 2008-12-12 13:28
        
        Simple mindedHelmut 2008-12-12 14:58
        
        SAS and WinNonlin d_labes 2008-12-12 15:44
        
        SAS and WinNonlin Helmut 2008-12-12 16:33
        
        SAS and WinNonlin BEQool 2024-07-29 09:38
        
        Phoenix RSABE-template Helmut 2024-07-29 13:29
        
        Phoenix RSABE-template BEQool 2024-07-29 19:47
        
        CVw in Phoenix RSABE-template Helmut 2024-07-30 09:15
        
        CVw in Phoenix RSABE-template BEQool 2024-07-30 10:56
        
        CVw in Phoenix RSABE-template and PowerTOST CI2CV() Helmut 2024-07-30 11:23
        
        CVw in Phoenix RSABE-template and PowerTOST CI2CV() BEQool 2024-07-31 05:49
        
        General ABE? mittyri 2024-07-31 18:25
        
        General ABE? BEQool 2024-08-01 05:45
        
        Switchability and Prescribability in WinNonlin MGR 2008-12-30 10:12
        
        PBE and IBE in WinNonlin Helmut 2008-12-30 16:04
        
        PBE and IBE in WinNonlin MGR 2008-12-31 07:52
        
        Switchability NPavan 2009-01-12 13:10