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Dear Helmut,
I am the last to tout "SAS all over the world" (although I have to deal with the 'power to know' most time of my working day). But here I must defend it.
I guess this is not a problem of SAS. It may be a problem of what we (I) do with it. Fitting an inappropriate? or over-specified? model.
Eventually anybody can fit the underlying model in WINNONLIN or R using REML to see what happens?
I have taken my data to play with from example 4.2 of Patterson/Jones "Bioequivalence and Statistics in Clinical Pharmacology" (C5300.zip with data and SAS code), changed the original sequences to TRR/RTR.
I place a bet that then also a fitted value for s2WT is obtained
. Maybe it is even correct!?
(I confabulate: total variability of T: estimable; variability of T-R: estimable and sum of intra-subject variabilities + treatment*subject interaction; intra-subject variability of R: estimable; so ......)
BTW: Simple minds are more then 30 years successful
.
❝ ❝ Black magic 
or some sort of perpetuum mobile of information?
❝
❝ Neither nor - just the 'power to know'!
❝ For my simple mind it seems to be quite strange to get the variance of a measurement we have performed only once.
I am the last to tout "SAS all over the world" (although I have to deal with the 'power to know' most time of my working day). But here I must defend it.
I guess this is not a problem of SAS. It may be a problem of what we (I) do with it. Fitting an inappropriate? or over-specified? model.
Eventually anybody can fit the underlying model in WINNONLIN or R using REML to see what happens?
I have taken my data to play with from example 4.2 of Patterson/Jones "Bioequivalence and Statistics in Clinical Pharmacology" (C5300.zip with data and SAS code), changed the original sequences to TRR/RTR.
I place a bet that then also a fitted value for s2WT is obtained
. Maybe it is even correct!? (I confabulate: total variability of T: estimable; variability of T-R: estimable and sum of intra-subject variabilities + treatment*subject interaction; intra-subject variability of R: estimable; so ......)
BTW: Simple minds are more then 30 years successful
.—
Regards,
Detlew
Regards,
Detlew
Complete thread:
- SAS code of partial replicate design pa1kumar.anna 2008-12-01 09:51 [Software]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Etiquette Ohlbe 2008-12-01 10:45
- SAS code for what? d_labes 2008-12-02 09:17
- partial replicate = 3-period replicate Helmut 2008-12-03 15:42
- partial replicate = 3-period replicate MGR 2008-12-04 11:19
- 3-period replicate designs and SAS d_labes 2008-12-04 14:17
- Extra-reference or partial replicate design d_labes 2008-12-12 10:51
- Extra-reference or partial replicate design Helmut 2008-12-12 11:34
- Simple mindedd_labes 2008-12-12 13:28
- Simple minded Helmut 2008-12-12 14:58
- SAS and WinNonlin d_labes 2008-12-12 15:44
- SAS and WinNonlin Helmut 2008-12-12 16:33
- Switchability and Prescribability in WinNonlin MGR 2008-12-30 10:12
- PBE and IBE in WinNonlin Helmut 2008-12-30 16:04
- PBE and IBE in WinNonlin MGR 2008-12-31 07:52
- Switchability NPavan 2009-01-12 13:10
- PBE and IBE in WinNonlin MGR 2008-12-31 07:52
- PBE and IBE in WinNonlin Helmut 2008-12-30 16:04
- SAS and WinNonlin d_labes 2008-12-12 15:44
- Simple minded Helmut 2008-12-12 14:58
- Simple mindedd_labes 2008-12-12 13:28
- Extra-reference or partial replicate design Helmut 2008-12-12 11:34
- Extra-reference or partial replicate design d_labes 2008-12-12 10:51
- partial replicate = 3-period replicate Helmut 2008-12-03 15:42
Ing. Helmut Schütz