Bioequivalence and Bioavailability Forum • How to Define Sampling Interval

How to Define Sampling Interval [Design Issues]

posted by eduardojmorales – 2006-10-06 01:16 (6832 d 13:22 ago) – Posting: # 281
Views: 13,237

❝ Hello I'm a beginner in BE and I can't seem to find sources of information on how to determine the sampling interval for each drug.

Even though a Chilean Guideline says you need to take enough samples to draw an accurate curve, it doesn't say how to determine it. The common calculation is 15 samples, 5 on each phase of the curve (ascending, peak, descending).
For practical purposes this would be enough; but do we have a parameter to calculate this? How do we know the minimmum number to get an accurate curve?

Complete thread:

How to Define Sampling Interval eduardojmorales 2006-10-05 21:11 [Design Issues]
- How to Define Sampling Intervaleduardojmorales 2006-10-05 23:16
  - Soliloquy? H_Rotter 2006-10-06 13:27
    - Soliloquy? eduardojmorales 2006-10-10 18:09
  - Algorithm (geometric progression) Helmut 2006-10-07 21:48
    - Algorithm (geometric progression) eduardojmorales 2006-10-10 18:23
      - Algorithm (geometric progression) Helmut 2006-10-10 19:05
    - Algorithm (geometric progression) intuitivepharma 2013-02-28 08:10
      - Geometric progression in Excel Helmut 2013-02-28 13:56
      - Sampling (optimization?) Helmut 2013-02-28 16:50
        
        Sampling (optimization?) intuitivepharma 2013-03-01 07:42
        
        Sampling (optimization?) SDavis 2013-03-07 10:40
        
        VIFs? Helmut 2013-03-07 15:50
        Sampling (optimization?) intuitivepharma 2013-03-08 12:39