90% CIs for BE? [🇷 for BE/BA]
Dear Yung-jin,
I agree with ElMaestro. BTW, Westlake’s CI should never be used and thrown into the statistical garbage collection because it obscures information about the location of the difference (I have not the slightest idea why it’s still used in WinNonlin).
Example from a study with low variability (CVintra 8.63%, n=12):
You have no clue that the BA of the test formulation is statistically significant (though not clinically relevant) higher than the reference’s.
I agree with ElMaestro. BTW, Westlake’s CI should never be used and thrown into the statistical garbage collection because it obscures information about the location of the difference (I have not the slightest idea why it’s still used in WinNonlin).
Example from a study with low variability (CVintra 8.63%, n=12):
Shortest CI: 100.54% – 113.52% (PE 106.84%)
Westlake’s CI: 88.06% – 111.94%
±11.94%
… 
- Westlake WJ. Symmetrical Confidence Intervals for Bioequivalence Trials. Biometrics. 1976;32(4):741–4. doi:10.2307/2529259.
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Dif-tor heh smusma 🖖🏼 Довге життя Україна!
![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png)
Helmut Schütz
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The quality of responses received is directly proportional to the quality of the question asked. 🚮
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Complete thread:
- 90% CIs for BE? yjlee168 2008-11-17 08:52 [🇷 for BE/BA]
- 90% CIs for BE? ElMaestro 2008-11-17 09:46
- 90% CIs for BE? d_labes 2008-11-17 13:07
- There can be only one! Helmut 2008-11-17 17:12
- 90% CIs for BE?Helmut 2008-11-17 13:30
- 90% CIs for BE? ElMaestro 2008-11-17 13:51
- 90% CIs for BE? d_labes 2008-11-17 13:56
- 90% CIs for BE? yjlee168 2008-11-17 18:10
- 90% CIs for BE? Helmut 2008-11-17 18:14
- 90% CIs for BE? yjlee168 2008-11-17 18:26
- 90% CIs for BE? ElMaestro 2008-11-17 19:49
- 90% CIs for BE? yjlee168 2008-11-17 18:26
- 90% CIs for BE? Helmut 2008-11-17 18:14
- 90% CIs for BE? ElMaestro 2008-11-17 13:51