Bioequivalence and Bioavailability Forum • bear v2.0.1 (upwards) cont'd

bear v2.0.1 (upwards) cont'd [🇷 for BE/BA]

posted by yjlee168 – Kaohsiung, Taiwan, 2008-10-28 09:59 (6076 d 23:09 ago) – Posting: # 2587
Views: 33,784
(edited on 2008-10-28 10:38)

dear EM,

Thank you for your message. No wonder that I cannot find anything about the method to analyze imbalanced sequence, BE data from US-FDA guideline. Yes, we've already been able to calculated Type I SS and Type III SS with bear right now. Thus, bear can analyze imbalanced or balanced sequence, BE data using lm method. In your message of previous thread, you said it might be "unsafe" if we used lm to analyze imbalanced BE data. And in the following replied message, you said it might be "unstable or incorrect" (from another forum) if we do so. Could you please give us more details about why you said so? What have you seen if one uses lm to analyze an imbalanced sequence BE? It sounds like lme or SAS PROC MIXED is preferred when analyzing imbalanced sequence BE. Am I correct?

—
All the best,
-- Yung-jin Lee
bear v2.9.2:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here

Complete thread:

bear v2.0.1 (upwards) cont'd yjlee168 2008-10-26 20:46 [🇷 for BE/BA]
- bear v2.0.1 (upwards) cont'd ElMaestro 2008-10-27 20:36
  - bear v2.0.1 (upwards) cont'dyjlee168 2008-10-28 08:59
    - bear v2.0.1 (upwards) cont'd ElMaestro 2008-10-28 09:49
      - Imbalance or incomplete data, SASophylistic view d_labes 2008-10-28 17:14
        
        Imbalance or incomplete data, SASophylistic view yjlee168 2008-10-29 07:36
        
        Incomplete cases d_labes 2008-10-29 09:24
        
        Incomplete cases yjlee168 2008-10-30 07:12
        
        Imbalance or incomplete data, SASophylistic view ElMaestro 2008-10-29 09:27
        
        Gold in discussion d_labes 2008-10-29 09:56
        
        Gold? Helmut 2008-10-29 13:03
        
        Imbalance or incomplete data, WinNonlin5.2.1 Helmut 2008-10-29 12:12
        
        Incomplete data, SAS9.2 d_labes 2008-10-29 16:38
        
        Missing values, imputation; separate study ElMaestro 2008-10-30 08:57
        Incomplete data, SAS9.2, DDF option residual d_labes 2008-10-30 15:54
        
        Never belief in any software you haven't written yourself Helmut 2008-10-30 16:30
        
        Imbalance or incomplete data, SASophylistic view yjlee168 2008-11-07 05:12
        
        Imbalance or incomplete data, SASophylistic view d_labes 2008-11-11 08:35
        
        Imbalance or incomplete data, SASophylistic view yjlee168 2008-11-11 08:54
        
        Imbalance or incomplete data, SASophylistic view d_labes 2008-11-11 13:13
        
        Imbalance or incomplete data, SASophylistic view yjlee168 2008-11-11 13:35
        
        Imbalance or incomplete data, SASophylistic view d_labes 2008-11-11 14:02
        
        Notification about new posts Helmut 2008-11-11 12:24
        
        Notification about new posts d_labes 2008-11-11 13:24
        
        3 Prerequisites for biostatistics Helmut 2008-11-11 13:39
        
        3 Prerequisites for biostatistics d_labes 2008-11-11 14:09