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RegisterNegative ƒ2 is possible [Study Assessment]
Hi Helmut,
I eventually tried a normalization method that dividing all concentration data by the average Cmax of the reference product. This gives me, in nearly all cases, positive f2 values. This is similar to the method described in this article, althogh I used the whole curve instead of the absorption phase.
I eventually tried a normalization method that dividing all concentration data by the average Cmax of the reference product. This gives me, in nearly all cases, positive f2 values. This is similar to the method described in this article, althogh I used the whole curve instead of the absorption phase.
Complete thread:
- Comparing two plasma concentration profiles Darborn 2025-10-17 05:40 [Study Assessment]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Comparing two plasma concentration profiles Helmut 2025-10-17 12:51
- Comparing two plasma concentration profiles Darborn 2025-10-21 01:02
- Comparing two plasma concentration profiles ElMaestro 2025-10-21 12:39
- Comparing two plasma concentration profiles Shuanghe 2025-10-29 16:27
- Comparing two plasma concentration profiles Darborn 2025-10-21 01:02
- Negative ƒ2 is possible Helmut 2025-10-30 15:40
- Interesting, however... ElMaestro 2025-11-03 14:15
- Negative ƒ2 is possibleDarborn 2025-11-07 06:04
- Comparing two plasma concentration profiles Helmut 2025-10-17 12:51
Ing. Helmut Schütz