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RegisterExample 4 in SASophylistic [🇷 for BE/BA]
Dear folks,
if you need an independent opinion (no R, no Far side but 'the power to know'
) here are the results of log-linear regression with SAS for example 4 up to 6 decimals, without point Cmax, tmax:
If I understood the algorithm right, 3 points in the terminal phase should be the solution.
From WinNONLIN users guide (dont know which version, found it on the Inder-net):
"[...] WinNonlin repeats regressions using the last three points with non-zero concentrations, then the last four points, last five, etc. Points prior to Cmax [...] are not used [...] For each regression, an adjusted R2 is computed [...] The regression with the largest adjusted R2 is selected to estimate lambdaZ, with these caveats:
If you use Cmax, tmax one gets:
If the algorithm is not serial (stop if no increase in adjR2), and this seems to be the case, then Nused=7;
if you need an independent opinion (no R, no Far side but 'the power to know'
) here are the results of log-linear regression with SAS for example 4 up to 6 decimals, without point Cmax, tmax:
N used lambdaZ Rsq Adj.Rsq
3 0.119676 0.996846 0.993692
4 0.126202 0.993931 0.990895
5 0.128630 0.994243 0.992324
6 0.127205 0.994425 0.993032
If I understood the algorithm right, 3 points in the terminal phase should be the solution.
From WinNONLIN users guide (dont know which version, found it on the Inder-net):
"[...] WinNonlin repeats regressions using the last three points with non-zero concentrations, then the last four points, last five, etc. Points prior to Cmax [...] are not used [...] For each regression, an adjusted R2 is computed [...] The regression with the largest adjusted R2 is selected to estimate lambdaZ, with these caveats:
- If the adjusted R2 does not improve, but is within 0.0001 of the largest adjusted R2 value, the regression with the larger number of points is used.
- lambdaZ must be positive, and calculated from at least three data points."
If you use Cmax, tmax one gets:
N used lambdaZ Rsq Adj.Rsq
7 0.127446 0.995071 0.994086
If the algorithm is not serial (stop if no increase in adjR2), and this seems to be the case, then Nused=7;
—
Regards,
Detlew
Regards,
Detlew
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- bear v1.0.0 - a data analytical tool for ABE in R yjlee168 2008-07-12 20:53 [🇷 for BE/BA]
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Ing. Helmut Schütz