Bioequivalence and Bioavailability Forum

Dear Martin,

Thank you for your detailed answer and the useful references!
I have a follow-up question regarding the PK R package. According to the documentation states:
HL and Vss are functions of the MRT and hence they will not be valid under oral administration.

Could you please clarify your position on this? In particular:

- Why doesn’t the package output Lambda_z directly, given that it’s estimated to compute AUCINF?
- Why is HL calculated from MRT rather than being derived as a function of Lambda_z, especially since these parameters are not valid for oral administration?

I appreciate your insights on these points and look forward to your explanation.