WinNonlin 5.2.1 vs. 6 beta [🇷 for BE/BA]
Dear Yung-jin,
wonderful!
I don’t know which version of WinNonlin you are using, but I could reproduce your results of Ex.04 in the current version v5.2.1. This is contradictory to the manual and the online help.
Now for the weird part. I tried the dataset also in WinNonlin v6 beta Phoenix and got:
As you can see only the last three data points were picked, although according to the manual the algorithm should be the same as in previous versions.
For both cases we should consider contacting Pharsight’s support to clarify the issue.
wonderful!
I don’t know which version of WinNonlin you are using, but I could reproduce your results of Ex.04 in the current version v5.2.1. This is contradictory to the manual and the online help.
Now for the weird part. I tried the dataset also in WinNonlin v6 beta Phoenix and got:
Summary Table
-------------
Time Conc. Pred. Residual AUC AUMC Weight
-------------------------------------------------------------------------------
0.0000 0.0000 0.0000 0.0000
0.2500 30.10 3.763 0.9406
0.5000 211.0 33.90 15.07
0.7500 1221. 212.9 142.7
1.000 1485. 551.2 442.8
1.500 1837. 1382. 1503.
2.000 1615. 2245. 2999.
3.000 1621. 3863. 7046.
4.000 1411. 5379. 1.230e+004
8.000 * 763.0 728.2 34.77 9727. 3.580e+004 1.000
12.00 * 424.0 451.2 -27.20 1.210e+004 5.818e+004 1.000
24.00 * 109.0 107.3 1.681 1.530e+004 1.044e+005 1.000
*) Starred values were included in the estimation of Lambda_z.
Final Parameters
---------------
Rsq 0.9968
Rsq_adjusted 0.9937
Corr_XY -0.9984
No_points_lambda_z 3
Lambda_z 0.1197
Lambda_z_lower 8.0000
Lambda_z_upper 24.0000
HL_Lambda_z 5.7919
...
As you can see only the last three data points were picked, although according to the manual the algorithm should be the same as in previous versions.
For both cases we should consider contacting Pharsight’s support to clarify the issue.
—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Thread locked
Complete thread:
- bear v1.0.0 - a data analytical tool for ABE in R yjlee168 2008-07-12 20:53 [🇷 for BE/BA]
- bear v1.0.0 for R - first impressions Helmut 2008-07-14 04:12
- bear v1.0.0 for R - first impressions yjlee168 2008-07-14 10:26
- bear v1.0.0 for R - first impressions Helmut 2008-07-14 14:02
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- WinNonlin 5.2.1 vs. 6 beta yjlee168 2008-09-29 18:45
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- TTT method for lambda_z estimation Aceto81 2008-09-30 15:11
- TTT method for lambda_z estimation yjlee168 2008-09-30 19:57
- TTT method for lambda_z estimation Aceto81 2008-10-01 14:18
- TTT method for lambda_z estimation yjlee168 2008-10-02 12:29
- TTT method for lambda_z estimation Aceto81 2008-10-03 15:33
- TTT method for lambda_z estimation yjlee168 2008-10-03 21:22
- TTT method for lambda_z estimation Aceto81 2008-10-03 15:33
- TTT method for lambda_z estimation yjlee168 2008-10-02 12:29
- TTT method for lambda_z estimation Aceto81 2008-10-01 14:18
- TTT method for lambda_z estimation yjlee168 2008-09-30 19:57
- TTT method for lambda_z estimation d_labes 2008-09-30 14:48
- lambda_z estimation d_labes 2008-09-23 14:41
- bear v1.0.0 - a data analytical tool for ABE in R yjlee168 2008-07-16 07:22
- bear v1.0.0 - a data analytical tool for ABE in R Aceto81 2008-07-15 10:07
- bear v1.0.0 - a data analytical tool for ABE in R yjlee168 2008-07-14 19:02
- bear v1.0.0 - a data analytical tool for ABE in R ElMaestro 2008-07-22 14:35
- bear v1.0.0 - a data analytical tool for ABE in R yjlee168 2008-07-23 09:55
- bear v1.0.0 - a data analytical tool for ABE in R ElMaestro 2008-07-24 10:04
- bear v1.0.0 - a data analytical tool for ABE in R yjlee168 2008-07-25 20:38
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- bear v1.0.0 - a data analytical tool for ABE in R yjlee168 2008-07-25 20:38
- bear v1.0.0 - a data analytical tool for ABE in R ElMaestro 2008-09-23 16:10
- bear v1.0.0 - a data analytical tool for ABE in R yjlee168 2008-09-24 22:00
- bear v1.0.0 - a data analytical tool for ABE in R ElMaestro 2008-09-25 09:03
- bear v1.0.0 - a data analytical tool for ABE in R ElMaestro 2008-09-25 13:52
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- bear v1.0.0 - a data analytical tool for ABE in R ElMaestro 2008-09-25 14:55
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- Thread locked Helmut 2008-10-24 11:58
- Only balanced, crossover BE studies? ElMaestro 2008-10-24 11:26
- Only balanced, crossover BE studies? yjlee168 2008-10-21 19:01
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