WinNonlin 5.2.1 vs. 6 beta [🇷 for BE/BA]

posted by Helmut Homepage – Vienna, Austria, 2008-09-29 17:54 (6105 d 08:15 ago) – Posting: # 2438
Views: 72,104

Dear Yung-jin,

wonderful!
I don’t know which version of WinNonlin you are using, but I could reproduce your results of Ex.04 in the current version v5.2.1. This is contradictory to the manual and the online help.
Now for the weird part. I tried the dataset also in WinNonlin v6 beta Phoenix and got:
Summary Table
-------------
      Time         Conc.      Pred.    Residual      AUC       AUMC      Weight
-------------------------------------------------------------------------------
     0.0000       0.0000                           0.0000     0.0000
     0.2500        30.10                            3.763     0.9406
     0.5000        211.0                            33.90      15.07
     0.7500        1221.                            212.9      142.7
      1.000        1485.                            551.2      442.8
      1.500        1837.                            1382.      1503.
      2.000        1615.                            2245.      2999.
      3.000        1621.                            3863.      7046.
      4.000        1411.                            5379. 1.230e+004
      8.000 *      763.0      728.2      34.77      9727. 3.580e+004      1.000
      12.00 *      424.0      451.2     -27.20 1.210e+004 5.818e+004      1.000
      24.00 *      109.0      107.3      1.681 1.530e+004 1.044e+005      1.000


*) Starred values were included in the estimation of Lambda_z.


Final Parameters
---------------
Rsq                                                       0.9968
Rsq_adjusted                                              0.9937
Corr_XY                                                  -0.9984
No_points_lambda_z                                        3
Lambda_z                                                  0.1197
Lambda_z_lower                                            8.0000
Lambda_z_upper                                           24.0000
HL_Lambda_z                                               5.7919
...

As you can see only the last three data points were picked, although according to the manual the algorithm should be the same as in previous versions. :confused:
For both cases we should consider contacting Pharsight’s support to clarify the issue.
—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! [image]
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Thread locked

Complete thread:

UA Flag
Activity
 Admin contact
23,424 posts in 4,927 threads, 1,674 registered users;
26 visitors (0 registered, 26 guests [including 17 identified bots]).
Forum time: 02:10 CEST (Europe/Vienna)

Truth and clarity are complementary.    Niels Bohr

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5