Log in
RegisterIssue with PBE Calculation when Stage = 1 [Regulatives / Guidelines]
Hello Weiguo2122,
When m=1 you have a between units variation (MSB = Mean Square Between) but you do not have a within-unit-variation (MSW = Mean Square Within). A mean square is a variance. The square root of a variance is a standard deviation. You see, at m=1 the entire right-hand side of whatever is under the square root sign disappears.
So, at m=1 the stdev for ref is the square root of MSB for that formulation.
❝ What approach should be used to calculate PBE when m = 1? Are there any alternative methods or approaches recommended in this scenario?
When m=1 you have a between units variation (MSB = Mean Square Between) but you do not have a within-unit-variation (MSW = Mean Square Within). A mean square is a variance. The square root of a variance is a standard deviation. You see, at m=1 the entire right-hand side of whatever is under the square root sign disappears.
So, at m=1 the stdev for ref is the square root of MSB for that formulation.
—
Pass or fail!
ElMaestro
Pass or fail!
ElMaestro
Complete thread:
- Issue with PBE Calculation when Stage = 1 weiguo2122 2025-01-13 20:19 [Regulatives / Guidelines]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Issue with PBE Calculation when Stage = 1ElMaestro 2025-01-13 21:08
- Issue with PBE Calculation when Stage = 1 weiguo2122 2025-01-15 20:45
- Issue with PBE Calculation when Stage = 1ElMaestro 2025-01-13 21:08
Ing. Helmut Schütz