Bioequivalence and Bioavailability Forum

Population BE [PBE] [Regulatives / Guidelines]

posted by jdfr – Portugal, 2025-01-07 18:10 (183 d 19:54 ago) – Posting: # 24327
Views: 4,820

Hi ElMaestro,

❝ From the top of my head I think the only thing they do not tell you in the guidance is that the sample data is already ln-tranformed.

Everything is clear now

❝ You would need to combine some mean squares for MSB as variability between comes from different units and different batches. I do not readily have a recipe. I am sure it can be worked out pretty easily, but again why do it when the guidance has a perfect example with equations for it?

I am having trouble translating the numerators into code, that's why I was trying to find an ANOVA that could give me both MSB and MSW but I fully understand that it is easier to code directly the formulas given. Should I calculate (mean(stage1)+mean(stage2)+mean(stage3))/number of stages?

Best regards,

Complete thread:

• Population BE [PBE] jdfr 2024-12-05 16:34 [Regulatives / Guidelines] 
  • Population BE [PBE] ElMaestro 2024-12-17 22:50
    • Population BE [PBE] jdfr 2025-01-06 11:14
      • Population BE [PBE] ElMaestro 2025-01-06 12:52
        • Population BE [PBE] jdfr 2025-01-07 12:08
          • Population BE [PBE] ElMaestro 2025-01-07 13:50
            • Population BE [PBE]jdfr 2025-01-07 17:10
              • Population BE [PBE] ElMaestro 2025-01-07 18:55
                • Population BE [PBE] jdfr 2025-01-08 10:13
                  • Population BE [PBE] ElMaestro 2025-01-08 11:02
                    • Population BE [PBE] jdfr 2025-01-08 17:45
                    • Population BE [PBE] jdfr 2025-01-09 09:16
                      • Population BE [PBE] ElMaestro 2025-01-09 14:46