Population BE [PBE] [Regulatives / Guidelines]

posted by jdfr – Portugal, 2025-01-07 13:08 (7 d 23:40 ago) – Posting: # 24325
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Hi ElMaestro,

Thank you very much for clarifying!
Should one use log transformed data? In step 1 it says so, but when calculating ED from table in step 3, the final value comes from calculating using mean values from the untransformed variable.

❝ That would in principle be correct, I think.


If I were to do an ANOVA to extract MSB and MSW, should I use a single effect of the containers or add any other effect to it? Doing so didn't lead me to achieve the same results as the ones found in the example.

❝ however if you ask me there is no reason to do so since the guidance (stop 2) directly gives the equations on how to calculate these quantities.


It might be easier that way, but I am having trouble in computing the numerator of both MSB and MSW. Any tip?

Also, could you clarify "Xbar ijk is the average m life stages for ith bottle in batch # j", please?

❝ I do not know of a package that does it for you. There may be smarter ways of doing it, but in my implementation I build / calculate the rows on the tables one by one and at the end all there's left is just a bit of summation to do. I follow strictly the calculation suggested in the guidance. To do so I need to understand the meaning of the notation.


Thank you for the clarification. I will compute them one by one, it shouldn't be that hard.

Many thanks in advance.

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