Bioequivalence and Bioavailability Forum • Groups: (Hardly‽) overlapping CIs

Groups: (Hardly‽) overlapping CIs [Design Issues]

posted by BEQool – 2024-11-22 13:32 (190 d 20:33 ago) – Posting: # 24291
Views: 2,915

Hello Helmut,

thank you for the example provided. Unfortunately, these kind of deficiency questions will probably become inevitable when conducting a study in groups.

❝ […] a separate exploratory analysis of each group was performed and produced the following outcomes

Did you perform this exploratory analysis of each group or did the agency do it?

❝ Therefore, the applicant should provide a justification for this difference and discuss its potential impact on the conclusion of bioequivalence.

❝ A new term: Hardly overlapping CIs. Again: So what? Justification?

How do you plan to "justify" this difference?

Regards
BEQool

Complete thread:

Possible reasons for group effect GM 2019-07-20 07:36 [Design Issues]
- Group “effect” Helmut 2019-07-20 14:02
- Possible reasons for group effect ElMaestro 2019-07-20 19:20
  - Possible reasons for group effect GM 2019-07-23 06:23
    - “Group-by-Treatment Interaction” Helmut 2019-07-23 10:32
      - “Group-by-Treatment Interaction” BEQool 2024-10-22 12:39
        
        “Group-by-Treatment Interaction” Helmut 2024-10-22 12:47
        
        OT: A choice between mittyri 2024-10-22 16:03
        
        OT: A choice between BEQool 2024-10-23 11:02
        
        OT: A choice between Helmut 2024-10-23 11:58
        
        OT: A choice between BEQool 2024-10-23 13:17
        
        OT: A choice between Helmut 2024-10-23 13:22
        Groups: Overlapping CIs Helmut 2024-11-03 11:36
        
        Groups: Overlapping CIs BEQool 2024-11-05 09:14
        
        Groups: Overlapping CIs Helmut 2024-11-05 10:12
        
        Groups: Overlapping CIs BEQool 2024-11-06 07:44
        
        Groups: (Hardly‽) overlapping CIs Helmut 2024-11-21 13:20
        
        Groups: (Hardly‽) overlapping CIsBEQool 2024-11-22 12:32
        
        Groups: (Hardly‽) overlapping CIs Helmut 2024-11-22 12:58
        Multiplicity? Helmut 2024-11-23 13:05
        
        Groups BEQool 2024-11-26 08:15