Groups: Overlapping CIs [Design Issues]

posted by BEQool  – 2024-11-06 08:44 (184 d 14:22 ago) – Posting: # 24262
Views: 2,939

Hello Helmut

❝ Let’s try a less extreme case with \(\small{\mu_1=0.825,\,\mu_2=1/\mu_1}\):

Simulated data

  n = 32

  group 1: n = 16, mue = 0.825

  group 2: n = 16, mue = 1.2121

Model I  (pooled data)

  p(G×T) = 0.040949

Model II (pooled data)

  PE     = 103.96%

  90% CI =  92.58 – 116.73%

  CVw    =  27.80%

Model III (group 1)

  PE     =  90.57%

  90% CI =  75.27 – 108.96%

  CVw    =  30.37%

Model III (group 2)

  PE     = 119.33%

  90% CI = 104.67 – 136.03%

  CVw    =  21.28%

❝ \(\small{p(\text{G}\times\text{T})}\) is significant and CIs of groups overlap. :-D


Yes true. The variability of group 1 is quite high - if we had similar variability than in group 2, then the 90% CIs wouldnt overlap :-D But then again, it makes sense and we all know that with larger sample size and lower variability we get narrower CIs and lesser chance of them overlapping so yes as can be seen it depends on case-by-case basis. :-)

Complete thread:

UA Flag
Activity
 Admin contact
23,424 posts in 4,927 threads, 1,669 registered users;
128 visitors (0 registered, 128 guests [including 7 identified bots]).
Forum time: 00:06 CEST (Europe/Vienna)

Freedom is always and exclusively
freedom for the one
who thinks differently.    Rosa Luxemburg

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5