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posted by martin  – Austria, 2008-09-27 11:37 (6107 d 20:56 ago) – Posting: # 2426
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(edited on 2008-09-27 13:28)

dear HS !

on the assumption of a one-compartmental open model (i.e. one compartmental absorption and one-compartmental elimination) I think that the lee method should be able to distinguish between the "mixture phase" (i.e. absorption and elimination) after Tmax and the pure elimination phase. You are right that Tmax is not a good starting point in the case of higher order models after extravascular administration.

I have to admit that I never performed simulations for the lee method in combination with extra-vascular compartmental models (I studied models after intravenous bolus administration). however, this discussion motivated me to set-up a few simulation scenarios and check the behaviour of the lee method to estimate the terminal elimination rate in such cases.

best regards

martin

PS.: I would very be happy if you could provide me some real life examples of one-compartmental open models (just parameter estimates no source data) to simulate log-normally distributed concentrations based on these models and check the performance of the lee method to select the elimination phase.

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