Bioequivalence and Bioavailability Forum

OT: A choice between [Design Issues]

posted by BEQool  – 2024-10-23 13:02 (39 d 06:24 ago) – Posting: # 24246
Views: 1,849

Dear Helmut,

❝ The original post is five years old… At the time being 0.05 indeed. The 0.1 was used by the FDA in analogy of Grizzle’s dreadful test¹ for unequal carryover.“

❝ [...]Make your pick.

Thanks for a thorough answer.
Regarding the choice of alpha level of 0.05 or 0.1 - every sponsor would probbaly choose 0.05 in order to decrease the chance of detecting an interaction?


Dear Mittyri,
good one (with alpha-value instead of p-value in the picture)
As written above, every sponsor would probably take the blue one


Regards
BEQool

Complete thread:

• Possible reasons for group effect GM 2019-07-20 07:36 [Design Issues] 
  • Group “effect” Helmut 2019-07-20 14:02
  • Possible reasons for group effect ElMaestro 2019-07-20 19:20
    • Possible reasons for group effect GM 2019-07-23 06:23
      • “Group-by-Treatment Interaction” Helmut 2019-07-23 10:32
        • “Group-by-Treatment Interaction” BEQool 2024-10-22 12:39
          • “Group-by-Treatment Interaction” Helmut 2024-10-22 12:47
            • OT: A choice between mittyri 2024-10-22 16:03
              • OT: A choice betweenBEQool 2024-10-23 11:02
                • OT: A choice between Helmut 2024-10-23 11:58
                  • OT: A choice between BEQool 2024-10-23 13:17
                    • OT: A choice between Helmut 2024-10-23 13:22
                    • Groups: Overlapping CIs Helmut 2024-11-03 11:36
                      • Groups: Overlapping CIs BEQool 2024-11-05 09:14
                        • Groups: Overlapping CIs Helmut 2024-11-05 10:12
                          • Groups: Overlapping CIs BEQool 2024-11-06 07:44
                            • Groups: (Hardly‽) overlapping CIs Helmut 2024-11-21 13:20
                              • Groups: (Hardly‽) overlapping CIs BEQool 2024-11-22 12:32
                                • Groups: (Hardly‽) overlapping CIs Helmut 2024-11-22 12:58
                                • Multiplicity? Helmut 2024-11-23 13:05
                                  • Groups BEQool 2024-11-26 08:15