PK Sampling Time Points - DR Formulation [Design Issues]
Dear Helmut,
Thanks for your kind response and the clarification. I appreciate it. It helped me to focus more!
Yes, I agree. Since the drug has major fraction absorbed in colon, I assumed it to be a SR formulation. But clearly in the plot, there is no significant lag time.
I believe, lag-time can be only observed in normal Conc-time plot. Isn't?
Thanks,
Titus
Thanks for your kind response and the clarification. I appreciate it. It helped me to focus more!
❝ In your original post you talked about an SR formulation. Locally applied, locally acting drugs (LALAs) are delayed release (DR). The correct model is simple (one or two compartments but with a substantial lag-time), which is not your current one.
Yes, I agree. Since the drug has major fraction absorbed in colon, I assumed it to be a SR formulation. But clearly in the plot, there is no significant lag time.
I believe, lag-time can be only observed in normal Conc-time plot. Isn't?
Thanks,
Titus
Complete thread:
- PK Sampling Time Points - SR Formulation TitusBen 2024-10-17 05:40 [Design Issues]
- PK Sampling Time Points - SR Formulation Helmut 2024-10-17 10:56
- PK Sampling Time Points - SR Formulation TitusBen 2024-10-18 06:24
- PK Sampling Time Points - DR Formulation Helmut 2024-10-18 09:16
- PK Sampling Time Points - DR FormulationTitusBen 2024-10-18 16:45
- lag-time – another round Helmut 2024-10-19 08:20
- PK Sampling Time Points - DR FormulationTitusBen 2024-10-18 16:45
- PK Sampling Time Points - DR Formulation Helmut 2024-10-18 09:16
- PK Sampling Time Points - SR Formulation TitusBen 2024-10-18 06:24
- PK Sampling Time Points - SR Formulation Helmut 2024-10-17 10:56