PK Sampling Time Points - DR Formulation [Design Issues]

posted by TitusBen – 2024-10-18 18:45 (16 d 05:14 ago) – Posting: # 24241
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Dear Helmut,

Thanks for your kind response and the clarification. I appreciate it. It helped me to focus more!

❝ In your original post you talked about an SR formulation. Locally applied, locally acting drugs (LALAs) are delayed release (DR). The correct model is simple (one or two compartments but with a substantial lag-time), which is not your current one.


Yes, I agree. Since the drug has major fraction absorbed in colon, I assumed it to be a SR formulation. But clearly in the plot, there is no significant lag time.

I believe, lag-time can be only observed in normal Conc-time plot. Isn't?

Thanks,
Titus

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