Bioequivalence and Bioavailability Forum

Hello J,

❝ I am going to try the following codes later today.

Did you try it? How did it go?

❝ What do you think?

❝ PROC MIXED data=BEdata;

❝ CLASSES SUBJECT TRT;

❝ MODEL logval = TRT/ DDFM=SATTERTH;

❝ RANDOM TRT/TYPE=FA0(2) SUB=SUBJECT G;

❝ REPEATED/GRP=TRT SUB=SUBJECT;

❝ ESTIMATE 'T vs. R' TRT 1 -1/CL ALPHA=0.1;

❝ lsmeans TRT/ cl alpha=0.1; * <-- for parallel design studies, alpha=0.1;

❝ ods output lsmeans=lsmeans;         * Least Squares means Output;

❝ ods output covparms=covparms;       * Covariance output;

❝ ods output estimates=ests;          * Estimate of differences between treatments;

I dont use SAS a lot and am therefore not an experienced user but I think you dont need statements in blue because you have a parallel design with just one factor Treatment.

And if you want to estimate T vs. R and have it coded like that, you should switch "1 -1" to "-1 1", otherwise with code "1 -1" you will get R vs. T and not T vs. R.
If you have it coded A vs. C (like in your first post) then "1 -1" is correct (it depends on the alphabetical order).

Regards
BEQool