Bioequivalence and Bioavailability Forum

Hi all,
I would like to do a meta BE analysis with treatment datasets (concentration vs time) from 2 separate BE studies that were conducted at different locations and at different time. The sample sizes are not the same (one is 36 and the other is 48). Both datasets (A from study 1, and B from study 2) have the same sampling time scheme and the same number of timepoints. For this analysis I would like to calculate the ratio of geometric means and 90% Geo CIs for Cmax and AUCs in SAS using a parallel study BE design setup. Can someone let me know if the following is correct? Do I need to check for Center and Center by treatment interaction as well?

  proc mixed data=PKEST;
  by paramn param;  /* Param is AUCs, or Cmax */
  class subject seq period trt center;
  model logval= seq period trt center center*trt/ddfm=satterth;
  random subject(seq); /* should this collapse to "random subject" since technically it would be single sequence for parallel design? */
  estimate  " A - C " TRT 1 -1 /cl alpha=0.1;
  lsmeans TRT /cl alpha=0.1; /* alpha is 0.1 since this is a parallel design comparison */
  ods output lsmeans=lsmeans;
  ods output covparms=covparms;
  ods output estimates=ests;
  run;

Thx
J