Bioequivalence and Bioavailability Forum

Treatment-by-Group in PROC MIXED and PROC GLM? [General Statistics]

posted by BEQool – 2024-10-07 12:27 (65 d 02:25 ago) – Posting: # 24220
Views: 1,302

❝ […] So you should prove why you modified your ANOVA to get F against Subject MS. […]

I mean if the Group*Treatment is a between-subject factor, it should be, in my opinion, tested by using Subject MS as the denominator.

❝ The `famous` Sun et al. paper states:

❝ For each dataset, a Linear Mixed Model is fit with subgroup, sequence, subgroup-by-sequence, period nested within subgroup, treatment, treatment-by-subgroup as the fixed model and subject nested within subgroup and sequence as a random effect model (the same model can also be fit using the General Linear Model (GLM) with fixed effects only but with slight modification).

As already discussed, you think that if they had used MS Subject as the denominator, they would have probably written it here?

❝ PS: Are you equipped with SAS to check the ANOVA tables for this model (using some dataset without dropouts?) It would be interesting to see what PROC MIXED thinks about this interaction. From this paper I assume they should be the same as PROC GLM. But who knows! I could be wrong with my claim...

Yes I have access to SAS but I dont exactly understand what would you like to know? Which dataset are you talking about? Some random dataset or a specific one? And you are talking about testing Group*Treatment interaction with this dataset with both PROC MIXED and PROC GLM and to see if there is any difference?

Regards
BEQool

Complete thread:

Group-by-Treatment Interaction: the final word? Helmut 2024-04-19 01:26 [General Statistics]
- Group-by-Treatment Interaction: FDA Helmut 2024-09-20 13:30
- Group-by-Treatment Interaction: the final word? BEQool 2024-10-03 15:09
  - ANOVA of Model 1 Helmut 2024-10-03 15:33
    - ANOVA of Model 1 BEQool 2024-10-03 16:08
      - ANOVA of Model 1 Helmut 2024-10-04 10:11
        
        Between vs Within mittyri 2024-10-05 00:08
        
        Between vs Within BEQool 2024-10-06 20:06
        
        Treatment-by-Group in PROC MIXED and PROC GLM? mittyri 2024-10-06 22:00
        
        Treatment-by-Group in PROC MIXED and PROC GLM?BEQool 2024-10-07 10:27
        
        Treatment-by-Group in PROC MIXED and PROC GLM? mittyri 2024-10-07 13:11
        
        Treatment-by-Group in PROC MIXED and PROC GLM? BEQool 2024-10-14 11:01

Treatment-by-Group in PROC MIXED and PROC GLM? [General Sta­tis­tics]

Complete thread:

Treatment-by-Group in PROC MIXED and PROC GLM? [General Statistics]