fixed or mixed effects model [BE/BA News]
❝ thank you for a well-explained answer with specific examples.
Welcome. No big deal because I had the simulation-script already.
❝ Doesnt a model with subject as a fixed effect automatically exlude subjects with missing periods (in 2x2x2 design) from the analysis? Or am I wrong?
Of course, you are right.
❝ If I am not wrong and if I understand correctly, based on your examples with incomplete data
(periods missing), the difference between subject as a fixed effect
and subject as a mixed effect
is more than a slight difference (instead the difference is observed in the 1st decimal place)?
Yes. That’s why I wrote:
❝ ❝ There are differences for incomplete data (period missing) – not only for the CI but also the PE.
❝ Yes I was most interested in these incomplete data
. So basically if you have incomplete data set (just periods missing) you should exclude the subject from the analysis and then the result (PI and 90%CI) would be almost the same (regardless of subject as a fixed or mixed effect)? Furthermore, this result would again be almost the same as if we wouldnt exclude the subject from the analysis and just used subject as a fixed effect?
Yep.
P.S.: I modified the script in such a way that you can specify the number of dropouts and subjects with missings. Try this:
CV <- 0.15
theta0 <- 0.975
target <- 0.90
alpha <- 0.05
per.effect <- 0
carryover <- c(0, 0)
dropouts <- 2
missings <- 1
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
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Science Quotes
Complete thread:
- ICH M13A: Changes to Step 2
Helmut 2024-07-31 13:16
- ICH M13A: Changes to Step 2 Helmut 2024-07-31 14:19
- AUCres mittyri 2024-08-05 21:08
- ‘Percentage covered’ Helmut 2024-08-05 22:13
- ICH M13A: Changes to Step 2 BEQool 2024-09-09 05:48
- fixed or mixed effects model Helmut 2024-09-09 07:04
- fixed or mixed effects model BEQool 2024-09-09 10:18
- fixed or mixed effects modelHelmut 2024-09-09 11:13
- fixed or mixed effects model BEQool 2024-09-10 07:35
- fixed or mixed effects modelHelmut 2024-09-09 11:13
- fixed or mixed effects model Helmut 2024-09-10 08:12
- fixed or mixed effects model BEQool 2024-09-09 10:18
- fixed or mixed effects model Helmut 2024-09-09 07:04
- AUCres mittyri 2024-08-05 21:08
- ICH M13A: Changes to Step 2 Helmut 2024-08-05 12:53
- period within group and formulation mittyri 2024-08-05 20:42
- period within group and formulation Helmut 2024-08-05 22:29
- ICH M13A: Step 4 → 5 Helmut 2024-08-08 11:57
- Formal ICH Procedure Helmut 2024-08-09 09:45
- ICH M13A: Changes to Step 2 Helmut 2024-09-06 08:04
- ICH M13A: Changes to Step 2 Helmut 2024-07-31 14:19