fixed or mixed effects model [BE/BA News]
thank you for a well-explained answer with specific examples.
❝ In a 2×2×2 crossover with subject(s) missing one period you get (apart from a slight difference in the nth figure, which is not relevant) the same result for a mixed effects model with all subject(s) and a fixed effects model excluding the subject(s) with missings.
If I am not wrong and if I understand correctly, based on your examples with
incomplete data
(periods missing), the difference between subject as a fixed effect
and subject as a mixed effect
is more than a slight difference (instead the difference is observed in the 1st decimal place)?❝ However, I would still use a mixed effects model for the FDA and Health Canada and a fixed effects model for all other agencies. We don’t want to confuse assessors who are used to what they required for ages.
❝ There are differences for incomplete data (period missing) – not only for the CI but also the PE. However, in such a case the subject should be excluded according to M13A and its Q&A anyway.
Yes I was most interested in these
incomplete data
. So basically if you have incomplete data set (just periods missing) you should exclude the subject from the analysis and then the result (PI and 90%CI) would be almost the same (regardless of subject as a fixed or mixed effect)? Furthermore, this result would again be almost the same as if we wouldnt exclude the subject from the analysis and just used subject as a fixed effect?Complete thread:
- ICH M13A: Changes to Step 2
Helmut 2024-07-31 13:16
- ICH M13A: Changes to Step 2 Helmut 2024-07-31 14:19
- AUCres mittyri 2024-08-05 21:08
- ‘Percentage covered’ Helmut 2024-08-05 22:13
- ICH M13A: Changes to Step 2 BEQool 2024-09-09 05:48
- fixed or mixed effects model Helmut 2024-09-09 07:04
- fixed or mixed effects modelBEQool 2024-09-09 10:18
- fixed or mixed effects model Helmut 2024-09-09 11:13
- fixed or mixed effects model BEQool 2024-09-10 07:35
- fixed or mixed effects model Helmut 2024-09-09 11:13
- fixed or mixed effects model Helmut 2024-09-10 08:12
- fixed or mixed effects modelBEQool 2024-09-09 10:18
- fixed or mixed effects model Helmut 2024-09-09 07:04
- AUCres mittyri 2024-08-05 21:08
- ICH M13A: Changes to Step 2 Helmut 2024-08-05 12:53
- period within group and formulation mittyri 2024-08-05 20:42
- period within group and formulation Helmut 2024-08-05 22:29
- ICH M13A: Step 4 → 5 Helmut 2024-08-08 11:57
- Formal ICH Procedure Helmut 2024-08-09 09:45
- ICH M13A: Changes to Step 2 Helmut 2024-09-06 08:04
- ICH M13A: Changes to Step 2 Helmut 2024-07-31 14:19