Bioequivalence and Bioavailability Forum

Hi Balu,

welcome to the forum!

❝ Dear Sir,

Incidentally I’m XY indeed.

❝ I'm recently using R software in clinical studies by calculating the pharmacokinetic and statistical analysis using BEAR Toolkit version 2.9.1.

bear is a package for . Do you come from the realm of Certara? Phoenix has toolkits.

❝ I'm facing the below mentioned error when i run the replicate cross-over designs.

Not quite. You successfully attached it after typing library(bear) because you saw …

… and got this error already at start, i.e., after typing go(). Did you follow the installation instructions exactly? I have no problems on Windows 7 and 11 (see this post).

Furthermore, I haven’t seen this ASCII-graph for ages (only with previous versions). I don’t see it running in R 4.1.3 (2022-03-10) and 4.4.1 (2024-06-14)… Therefore, I suspect that something went wrong with your installation.

I suggest to deinstall it: In the R-GUI type remove.packages("bear"). Down­load it again and follow the installation instructions (particularly run the script preinst.r from SourceForge).

If that doesn’t resolve your problem, I’m afraid you have to wait till Yung-jin passes by. Perhaps you can contact him directly (email in his profile). Alternatively, after library(bear) type help(p = bear) and click on the first link DESCRIPTION file to get his contact.

---

• I strongly suggest to always update to the latest version of R (current as of today is 4.4.1). For the procedure see this article. Sooner or later with version 4.1.3 you will face a situation where a package is no more supported. Furthermore, bugs are fixed in later versions, functions might be deprecated or even removed, and new ones introduced.
  For the procedure to use library(bear) with newer versions of R see this post.
  
• Please upload screenshots as (8-bit = 256 colors) PNGs. JPEGs are blurred and full of compression artifacts, esp. after downscaling.