Bioequivalence and Bioavailability Forum • Unconjugated ≠ free

Unconjugated ≠ free [Bioanalytics]

posted by Helmut – Vienna, Austria, 2024-08-13 09:31 (332 d 13:46 ago) – Posting: # 24155
Views: 4,251

Dear Ohlbe,

❝ The draft FDA dabigatran product-specific guidance uses "free" to designate non-conjugated dabigatran and "total" for the sum of non-conjugated + conjugated dabigatran, measured after hydrolysis of the conjugates. I can live with "total", but "free" is a misnomer IMHO.

That’s not a misnomer, it is not even wrong. No chemists at the FDA? BTW, the correct term is ‘unconjugated’.
Reminds me on this ‘goody’.

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz

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Complete thread:

A dumb question jag009 2024-08-12 13:17 [Bioanalytics]
- A dumb answer Helmut 2024-08-12 13:45
  - A dumb answer jag009 2024-08-12 14:35
    - A dumb answer Helmut 2024-08-12 15:01
      - A dumb answer ElMaestro 2024-08-12 15:13
        
        A dumb answer Helmut 2024-08-12 15:30
- An alternate dumb answer Ohlbe 2024-08-12 21:37
  - An alternate dumb answer jag009 2024-08-13 06:27
  - Unconjugated ≠ freeHelmut 2024-08-13 07:31
    - Unconjugated ≠ free jag009 2024-08-26 16:19
- A dumb question Achievwin 2024-08-27 03:02