Unconjugated ≠ free [Bioanalytics]

posted by Helmut Homepage – Vienna, Austria, 2024-08-13 09:31 (240 d 17:09 ago) – Posting: # 24155
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Dear Ohlbe,

❝ The draft FDA dabigatran product-specific guidance uses "free" to designate non-conjugated dabigatran and "total" for the sum of non-conjugated + conjugated dabigatran, measured after hydrolysis of the conjugates. I can live with "total", but "free" is a misnomer IMHO.

That’s not a misnomer, it is not even wrong. No chemists at the FDA? BTW, the correct term is ‘unconjugated’.
Reminds me on this ‘goody’.

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