Bioequivalence and Bioavailability Forum • An alternate dumb answer

An alternate dumb answer [Bioanalytics]

posted by jag009 – NJ, 2024-08-13 08:27 (307 d 15:18 ago) – Posting: # 24153
Views: 3,742

Hi Ohlbe,

Free = unbound drug concentration
Total drug = unbound + bound (to plasma protein).

FYI, FDA has a BEBA guidance for this drug but it doesn't ask to measure free drug or total drug.

The reason I asked this q is because I emailed the lab and they told me they measured unbound drug but I have a feeling that they answered my question incorrectly.

Thx
J

Complete thread:

A dumb question jag009 2024-08-12 13:17 [Bioanalytics]
- A dumb answer Helmut 2024-08-12 13:45
  - A dumb answer jag009 2024-08-12 14:35
    - A dumb answer Helmut 2024-08-12 15:01
      - A dumb answer ElMaestro 2024-08-12 15:13
        
        A dumb answer Helmut 2024-08-12 15:30
- An alternate dumb answer Ohlbe 2024-08-12 21:37
  - An alternate dumb answerjag009 2024-08-13 06:27
  - Unconjugated ≠ free Helmut 2024-08-13 07:31
    - Unconjugated ≠ free jag009 2024-08-26 16:19
- A dumb question Achievwin 2024-08-27 03:02