An alternate dumb answer [Bioanalytics]
Hi John,
Define free and total...
The draft FDA dabigatran product-specific guidance uses "free" to designate non-conjugated dabigatran and "total" for the sum of non-conjugated + conjugated dabigatran, measured after hydrolysis of the conjugates. I can live with "total", but "free" is a misnomer IMHO.
In this particular case you will get 2 bioanalytical reports, one for "free" and one for "total", which should be clearly identified.
Define free and total...
The draft FDA dabigatran product-specific guidance uses "free" to designate non-conjugated dabigatran and "total" for the sum of non-conjugated + conjugated dabigatran, measured after hydrolysis of the conjugates. I can live with "total", but "free" is a misnomer IMHO.
In this particular case you will get 2 bioanalytical reports, one for "free" and one for "total", which should be clearly identified.
—
Regards
Ohlbe
Regards
Ohlbe
Complete thread:
- A dumb question jag009 2024-08-12 13:17 [Bioanalytics]
- A dumb answer Helmut 2024-08-12 13:45
- A dumb answer jag009 2024-08-12 14:35
- A dumb answer Helmut 2024-08-12 15:01
- A dumb answer ElMaestro 2024-08-12 15:13
- A dumb answer Helmut 2024-08-12 15:30
- A dumb answer ElMaestro 2024-08-12 15:13
- A dumb answer Helmut 2024-08-12 15:01
- A dumb answer jag009 2024-08-12 14:35
- An alternate dumb answerOhlbe 2024-08-12 21:37
- An alternate dumb answer jag009 2024-08-13 06:27
- Unconjugated ≠ free Helmut 2024-08-13 07:31
- Unconjugated ≠ free jag009 2024-08-26 16:19
- A dumb question Achievwin 2024-08-27 03:02
- A dumb answer Helmut 2024-08-12 13:45