Bioequivalence and Bioavailability Forum • A dumb answer

A dumb answer [Bioanalytics]

posted by Helmut – Vienna, Austria, 2024-08-12 17:01 (270 d 20:03 ago) – Posting: # 24149
Views: 2,657

Hi John,

❝ ❝ Are you talking about a drug with protein binding? In […] protein-precipitation the protein-drug bonds will be practically immediately cleaved and therefore, from the extract you get always the total concentration.

❝ Yes, according to the text it was protein-precipitation extraction from plasma during sample pre-treatment phase. It's a drug w high protein binding. So it's total drug?

I know it’s Monday, but…

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Complete thread:

A dumb question jag009 2024-08-12 13:17 [Bioanalytics]
- A dumb answer Helmut 2024-08-12 13:45
  - A dumb answer jag009 2024-08-12 14:35
    - A dumb answerHelmut 2024-08-12 15:01
      - A dumb answer ElMaestro 2024-08-12 15:13
        
        A dumb answer Helmut 2024-08-12 15:30
- An alternate dumb answer Ohlbe 2024-08-12 21:37
  - An alternate dumb answer jag009 2024-08-13 06:27
  - Unconjugated ≠ free Helmut 2024-08-13 07:31
    - Unconjugated ≠ free jag009 2024-08-26 16:19
- A dumb question Achievwin 2024-08-27 03:02