A dumb answer [Bioanalytics]

posted by jag009  – NJ, 2024-08-12 16:35 (270 d 14:07 ago) – Posting: # 24148
Views: 2,667

Hi Helmut,

❝ ❝ A dumb question …

❝ You know that there are no dump questions.


Just a way to catch your attention :-P

❝ Are you talking about a drug with protein binding? That’s easy. Protein binding is caused by Van der Waals force, which is extremely weak. In a nutshell, in any extraction (liquid-liquid, solid-phase), or protein-precipitation the protein-drug bonds will be practically imme­dia­tely cleaved and therefore, from the extract you get always the total concentration.


Yes, according to the text it was protein-precipitation extraction from plasma during sample pre-treatment phase. It's a drug w high protein binding. So it's total drug?

Thx
J

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