Inducers/inhibitors [Regulatives / Guidelines]

posted by Ohlbe – France, 2024-08-08 20:09 (337 d 16:02 ago) – Posting: # 24143
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Dear Helmut,

❝ In a FDC half lives of components are generally different. In a drug with two isomers the half lives are likely different as well. Therefore, #2 because the washout was long enough for the respective other drug / isomer.


Yes, but... what if the drug which is still detected induces or inhibits the metabolism of the drug which is no longer detected ?

Regards
Ohlbe

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