Bioequivalence and Bioavailability Forum • Inducers/inhibitors

Inducers/inhibitors [Regulatives / Guidelines]

posted by Ohlbe – France, 2024-08-08 20:09 (238 d 01:18 ago) – Posting: # 24143
Views: 2,076

Dear Helmut,

❝ In a FDC half lives of components are generally different. In a drug with two isomers the half lives are likely different as well. Therefore, #2 because the washout was long enough for the respective other drug / isomer.

Yes, but... what if the drug which is still detected induces or inhibits the metabolism of the drug which is no longer detected ?

—
Regards
Ohlbe

Complete thread:

Predose concentration more than 5 % of Cmax NK 2024-08-05 06:07 [Regulatives / Guidelines]
- FDC or isomers: C0 > 5 % of Cmax Helmut 2024-08-05 08:36
  - FDC or isomers: C0 > 5 % of Cmax Achievwin 2024-08-05 19:08
    - Carryover. A Never Ending Story. Helmut 2024-08-05 22:39
  - Inducers/inhibitorsOhlbe 2024-08-08 18:09
    - Inducers/inhibitors Helmut 2024-08-09 08:26
- Predose concentration more than 5 % of Cmax qualityassurance 2024-08-05 12:48