IV: Liposome encapsuled drug, pegylated biologic? [Off Topic]

posted by Helmut Homepage – Vienna, Austria, 2024-08-02 09:52 (348 d 04:36 ago) – Posting: # 24125
Views: 3,482

Hi Darborn,

❝ It do has a longer half-life, …

I cannot imagine any case where this is possible for a small molecule. Is it a liposome encapsulated1 drug (doxorubicin, cisplatin, amphotericin B, …) or pegylated2 biologic (filgrastim, recombinant factor VIII, …)?


  1. Liu P, Chen G, Zhang J. A Review of Liposomes as a Drug Delivery System: Current Status of Approved Products, Regulatory Environments, and Future Perspectives. Molecules. 2022; 27(4): 1372. [image] Open access doi:10.3390/molecules27041372.
  2. Gao Y, Josh, Zhao Z, Mitragotri S. PEGylated therapeutics in the clinic. Bioeng Transl Med. 2024; 9(1): e10600. doi:10.1002/btm2.10600. [image] Free Full text.

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