Bioequivalence and Bioavailability Forum • IV: Liposome encapsuled drug, pegylated biologic?

IV: Liposome encapsuled drug, pegylated biologic? [Off Topic]

posted by Helmut – Vienna, Austria, 2024-08-02 09:52 (66 d 04:38 ago) – Posting: # 24125
Views: 1,239

Hi Darborn,

❝ It do has a longer half-life, …

I cannot imagine any case where this is possible for a small molecule. Is it a liposome encapsulated¹ drug (doxorubicin, cisplatin, amphotericin B, …) or pegylated² biologic (filgrastim, recombinant factor VIII, …)?

Liu P, Chen G, Zhang J. A Review of Liposomes as a Drug Delivery System: Current Status of Approved Products, Regulatory Environments, and Future Perspectives. Molecules. 2022; 27(4): 1372. Open access doi:10.3390/molecules27041372.
Gao Y, Josh, Zhao Z, Mitragotri S. PEGylated therapeutics in the clinic. Bioeng Transl Med. 2024; 9(1): e10600. doi:10.1002/btm2.10600. Free Full text.

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Complete thread:

A boring question about bioavailability? Darborn 2024-08-01 09:05 [Off Topic]
- ƒ of IV = 1 by definition, but… Helmut 2024-08-01 12:05
  - ƒ of IV = 1 by definition, but… Darborn 2024-08-01 12:36
    - IV: Different half-lives? Helmut 2024-08-01 13:43
      - IV: Different half-lives? Darborn 2024-08-02 02:39
        
        IV: Liposome encapsuled drug, pegylated biologic?Helmut 2024-08-02 07:52
        
        IV: Liposome encapsuled drug, pegylated biologic? Darborn 2024-08-06 05:15