Bioequivalence and Bioavailability Forum

CVw in Phoenix RSABE-template [Software]

posted by BEQool  – 2024-07-30 12:56 (191 d 02:55 ago) – Posting: # 24105
Views: 3,738

❝ Do I get you right that you want to get the within-subject within-subject \(\small{CV_\text{w}}\)?

Yes you are right.

❝ [...] I got for the EMA’s Example Data Set I: 41.620277

Thank you for the explanation and equations, I get the same CVw for the EMA Data Set I.

❝ BTW, why do you need it?

Because I want to get CVw from a full replicate (n=10) pilot study and the a) CVw obtained with your equation (1) does not match (not even close) b) CVw obtained from the 90% CI with CVfromCI (PowerTOST in R).

a )
Var(Period*Formulation*Subject)_21=0.020549392
Var(Period*Formulation*Subject)_22=0.18248611

CVw=SQRT(EXP((0.020549392+0.18248611)/2)-1)= 32.7%

b)
Lower=80.633903
Upper=122.74948

CVfromCI(lower=.80633903,upper=1.2274948,design="2x2x4",n=10)
[1] 0.4048149 --> 40.5%

Why is there such a difference here between the two CVw? The study is balanced with complete data. Can the reason be a relatively big difference between variability of test and reference?

BEQool

---

BTW

❝ $$s_\text{w}^2=\frac{s_\text{wR}^2+s_\text{wR}^2}{2}\tag{1}$$

and

❝ You should get a table with the estimated \(\small{s_\text{wR}^2}\) in the first row and \(\small{s_\text{wR}^2}\) in the second.

A small typo here - \(\small{s_\text{wR}^2}\) appears twice

Complete thread:

• SAS code of partial replicate design pa1kumar.anna 2008-12-01 09:51 [Software] 
  • Etiquette Ohlbe 2008-12-01 10:45
  • SAS code for what? d_labes 2008-12-02 09:17
    • partial replicate = 3-period replicate Helmut 2008-12-03 15:42
      • partial replicate = 3-period replicate MGR 2008-12-04 11:19
      • 3-period replicate designs and SAS d_labes 2008-12-04 14:17
        • Extra-reference or partial replicate design d_labes 2008-12-12 10:51
          • Extra-reference or partial replicate design Helmut 2008-12-12 11:34
            • Simple minded d_labes 2008-12-12 13:28
              • Simple minded Helmut 2008-12-12 14:58
                • SAS and WinNonlin d_labes 2008-12-12 15:44
                  • SAS and WinNonlin Helmut 2008-12-12 16:33
                    • SAS and WinNonlin BEQool 2024-07-29 09:38
                      • Phoenix RSABE-template Helmut 2024-07-29 13:29
                        • Phoenix RSABE-template BEQool 2024-07-29 19:47
                          • CVw in Phoenix RSABE-template Helmut 2024-07-30 09:15
                            • CVw in Phoenix RSABE-templateBEQool 2024-07-30 10:56
                              • CVw in Phoenix RSABE-template and Power­TOST CI2CV() Helmut 2024-07-30 11:23
                                • CVw in Phoenix RSABE-template and Power­TOST CI2CV() BEQool 2024-07-31 05:49
                                  • General ABE? mittyri 2024-07-31 18:25
                                    • General ABE? BEQool 2024-08-01 05:45
                • Switchability and Prescribability in WinNonlin MGR 2008-12-30 10:12
                  • PBE and IBE in WinNonlin Helmut 2008-12-30 16:04
                    • PBE and IBE in WinNonlin MGR 2008-12-31 07:52
                      • Switchability NPavan 2009-01-12 13:10