Bioequivalence and Bioavailability Forum • CVw in Phoenix RSABE-template

CVw in Phoenix RSABE-template [Software]

posted by BEQool – 2024-07-30 12:56 (48 d 18:31 ago) – Posting: # 24105
Views: 2,230

❝ Do I get you right that you want to get the within-subject within-subject $\small{CV_\text{w}}$?

Yes you are right.

❝ [...] I got for the EMA’s Example Data Set I: 41.620277

Thank you for the explanation and equations, I get the same CVw for the EMA Data Set I.

❝ BTW, why do you need it?

Because I want to get CVw from a full replicate (n=10) pilot study and the a) CVw obtained with your equation (1) does not match (not even close) b) CVw obtained from the 90% CI with CVfromCI (PowerTOST in R).

a )
Var(Period*Formulation*Subject)_21=0.020549392
Var(Period*Formulation*Subject)_22=0.18248611

CVw=SQRT(EXP((0.020549392+0.18248611)/2)-1)= 32.7%

b)
Lower=80.633903
Upper=122.74948

CVfromCI(lower=.80633903,upper=1.2274948,design="2x2x4",n=10)

[1] 0.4048149

--> 40.5%

Why is there such a difference here between the two CVw? The study is balanced with complete data. Can the reason be a relatively big difference between variability of test and reference?

BEQool

BTW

❝ $$s_\text{w}^2=\frac{s_\text{wR}^2+s_\text{wR}^2}{2}\tag{1}$$

and

❝ You should get a table with the estimated $\small{s_\text{wR}^2}$ in the first row and $\small{s_\text{wR}^2}$ in the second.

A small typo here - $\small{s_\text{wR}^2}$ appears twice :-)

Complete thread:

SAS code of partial replicate design pa1kumar.anna 2008-12-01 09:51 [Software]
- Etiquette Ohlbe 2008-12-01 10:45
- SAS code for what? d_labes 2008-12-02 09:17
  - partial replicate = 3-period replicate Helmut 2008-12-03 15:42
    - partial replicate = 3-period replicate MGR 2008-12-04 11:19
    - 3-period replicate designs and SAS d_labes 2008-12-04 14:17
      - Extra-reference or partial replicate design d_labes 2008-12-12 10:51
        
        Extra-reference or partial replicate design Helmut 2008-12-12 11:34
        
        Simple minded d_labes 2008-12-12 13:28
        
        Simple minded Helmut 2008-12-12 14:58
        
        SAS and WinNonlin d_labes 2008-12-12 15:44
        
        SAS and WinNonlin Helmut 2008-12-12 16:33
        
        SAS and WinNonlin BEQool 2024-07-29 09:38
        
        Phoenix RSABE-template Helmut 2024-07-29 13:29
        
        Phoenix RSABE-template BEQool 2024-07-29 19:47
        
        CVw in Phoenix RSABE-template Helmut 2024-07-30 09:15
        
        CVw in Phoenix RSABE-templateBEQool 2024-07-30 10:56
        
        CVw in Phoenix RSABE-template and PowerTOST CI2CV() Helmut 2024-07-30 11:23
        
        CVw in Phoenix RSABE-template and PowerTOST CI2CV() BEQool 2024-07-31 05:49
        
        General ABE? mittyri 2024-07-31 18:25
        
        General ABE? BEQool 2024-08-01 05:45
        
        Switchability and Prescribability in WinNonlin MGR 2008-12-30 10:12
        
        PBE and IBE in WinNonlin Helmut 2008-12-30 16:04
        
        PBE and IBE in WinNonlin MGR 2008-12-31 07:52
        
        Switchability NPavan 2009-01-12 13:10