Bioequivalence and Bioavailability Forum • CVw in Phoenix RSABE-template

CVw in Phoenix RSABE-template [Software]

posted by Helmut – Vienna, Austria, 2024-07-30 11:15 (46 d 11:02 ago) – Posting: # 24104
Views: 2,207

Hi BEQool,

❝ I still cannot find an object where I would find CVw:

Do I get you right that you want to get the within-subject within-subject $\small{CV_\text{w}}$? The template gives you only the within-subject of the reference $\small{CV_\text{wR}}$. Start with the pooled variance$$s_\text{w}^2=\frac{s_\text{wR}^2+s_\text{wT}^2}{2}\tag{1}$$and then as usual$$CV_\text{w}\,(\%)=100\,\sqrt{\exp(s_\text{w}^2)-1}\tag{2}$$My setup:

FDA RSABE Project template_ v8_3_3
[image] Workflow
       [image] ABE
           Results → Output Data → Final Variance Parameters
           right click, Send to ► Data Management ► D_w Data Wizard → Select Object → ABE
Filter → Add ⦿ Selection (Exclude) → highlight the first three rows OK
▶️ in the top menu to execute
You should get a table with the estimated $\small{s_\text{wR}^2}$ in the first row and $\small{s_\text{wT}^2}$ in the second.

Add a Transformation
Transformation Type
Custom
Transformation
Custom Transformation
New Column Name
CVw
Formula
100*sqrt(exp(sum(D:D)/2)-1)
▶️ in the top menu to execute
You should get a table with the estimated $\small{CV_\text{w}}$ in percent in the last column. I got for the EMA’s Example Data Set I: 41.620277
Of course, we get two rows. I leave the cosmetics to you.

BTW, why do you need it?

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Complete thread:

SAS code of partial replicate design pa1kumar.anna 2008-12-01 09:51 [Software]
- Etiquette Ohlbe 2008-12-01 10:45
- SAS code for what? d_labes 2008-12-02 09:17
  - partial replicate = 3-period replicate Helmut 2008-12-03 15:42
    - partial replicate = 3-period replicate MGR 2008-12-04 11:19
    - 3-period replicate designs and SAS d_labes 2008-12-04 14:17
      - Extra-reference or partial replicate design d_labes 2008-12-12 10:51
        
        Extra-reference or partial replicate design Helmut 2008-12-12 11:34
        
        Simple minded d_labes 2008-12-12 13:28
        
        Simple minded Helmut 2008-12-12 14:58
        
        SAS and WinNonlin d_labes 2008-12-12 15:44
        
        SAS and WinNonlin Helmut 2008-12-12 16:33
        
        SAS and WinNonlin BEQool 2024-07-29 09:38
        
        Phoenix RSABE-template Helmut 2024-07-29 13:29
        
        Phoenix RSABE-template BEQool 2024-07-29 19:47
        
        CVw in Phoenix RSABE-templateHelmut 2024-07-30 09:15
        
        CVw in Phoenix RSABE-template BEQool 2024-07-30 10:56
        
        CVw in Phoenix RSABE-template and PowerTOST CI2CV() Helmut 2024-07-30 11:23
        
        CVw in Phoenix RSABE-template and PowerTOST CI2CV() BEQool 2024-07-31 05:49
        
        General ABE? mittyri 2024-07-31 18:25
        
        General ABE? BEQool 2024-08-01 05:45
        
        Switchability and Prescribability in WinNonlin MGR 2008-12-30 10:12
        
        PBE and IBE in WinNonlin Helmut 2008-12-30 16:04
        
        PBE and IBE in WinNonlin MGR 2008-12-31 07:52
        
        Switchability NPavan 2009-01-12 13:10