simulating dissolution data beyond observed lab data [Dissolution / BCS / IVIVC]

posted by Helmut Homepage – Vienna, Austria, 2024-06-07 18:30 (11 d 17:50 ago) – Posting: # 24025
Views: 444

Hi Achievwin,

❝ Can anyone point out me towards a step by step process for modeling and simulating dissolution data for prolonged duration (0-90 days) based on the lab data for a defined period (0-10 days)?

If your cumulative dissolution is visually flattening, yes. Otherwise, you are fishing in the dark. Can you post some data?

❝ Can we use R for this exercise [?]

Likely. It depends on the number of parameters of the function you will fit (e.g., monoexponential, Weibull…) and sampling time points you have. In any case, the confidence interval of the prediction beyond the observed data may become terribly wide, rendering this exercise a game of chance.

Dif-tor heh smusma 🖖🏼 Довге життя Україна! [image]
Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

UA Flag
 Admin contact
23,057 posts in 4,840 threads, 1,641 registered users;
164 visitors (0 registered, 164 guests [including 10 identified bots]).
Forum time: 12:20 CEST (Europe/Vienna)

Even though it’s applied science we’re
dealin’ with, it still is – science!    Leslie Z. Benet

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz