simulating dissolution data beyond observed lab data [Dissolution / BCS / IVIVC]

posted by Helmut Homepage – Vienna, Austria, 2024-06-07 18:30 (11 d 17:50 ago) – Posting: # 24025
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Hi Achievwin,

❝ Can anyone point out me towards a step by step process for modeling and simulating dissolution data for prolonged duration (0-90 days) based on the lab data for a defined period (0-10 days)?

If your cumulative dissolution is visually flattening, yes. Otherwise, you are fishing in the dark. Can you post some data?

❝ Can we use R for this exercise [?]

Likely. It depends on the number of parameters of the function you will fit (e.g., monoexponential, Weibull…) and sampling time points you have. In any case, the confidence interval of the prediction beyond the observed data may become terribly wide, rendering this exercise a game of chance.

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