lambda_z estimation [🇷 for BE/BA]

posted by Aceto81 – Belgium, 2008-09-25 12:56 (5684 d 15:01 ago) – Posting: # 2401
Views: 55,849

❝ I do not own WINNONLIN, but I suggest that the point tmax, Cmax should not be included in the terminal part.

❝

❝ I further suggest that the TTT (two-times tmax) rule should be implemented to restrict the number of points in the terminal part, provided that at least 3 points are available.

❝ See this thread for the TTT rule.

❝

❝ May be the Akaike information criterion AIC (especially the AICc, small sample formula) is a better choice than adj. RSquare.


If the Cmax may not be included, this explains the difference between the R code and WinNonlin.
If you change
   for (i in (nrow(dat)-3):which.max(dat$conc))
to
   for (i in (nrow(dat)-3):(which.max(dat$conc)+1))
then Cmax is excluded.

And you would get the same result as WinNonlin.

Ace
Thread locked

Complete thread:

UA Flag
Activity
 Admin contact
22,987 posts in 4,824 threads, 1,668 registered users;
79 visitors (0 registered, 79 guests [including 5 identified bots]).
Forum time: 03:57 CEST (Europe/Vienna)

The only way to comprehend what mathematicians mean by Infinity
is to contemplate the extent of human stupidity.    Voltaire

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5