Assumptions (plural) [Design Issues]

posted by Helmut Homepage – Vienna, Austria, 2024-05-06 17:31 (43 d 00:04 ago) – Posting: # 23987
Views: 1,176

Hi Achievwin,

❝ How come we have three different N with same assumptions?

As outlined above, you can make three different assumptions.
  1. Uncertain CV → n = 28
  2. Uncertain T/R-ratio → n = 44
  3. Uncertain CV and uncertain T/R-ratio → n = 48
As always with Bayesian methods, the Prior is important. Play with my example and change the size of the pilot study (i.e., the value m). The smaller, the larger the sample size of the next. There­fore, small pilot studies are not a good idea. It may sound stupid, but the best for sample size estimation is a failed pivotal study… :-D

Dif-tor heh smusma 🖖🏼 Довге життя Україна! [image]
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

UA Flag
Activity
 Admin contact
23,057 posts in 4,840 threads, 1,641 registered users;
31 visitors (0 registered, 31 guests [including 7 identified bots]).
Forum time: 17:35 CEST (Europe/Vienna)

You should treat as many patients as possible with the new drugs
while they still have the power to heal.    Armand Trousseau

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5