Assumptions (plural) [Design Issues]

posted by Helmut Homepage – Vienna, Austria, 2024-05-06 17:31 (14 d 12:11 ago) – Posting: # 23987
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Hi Achievwin,

❝ How come we have three different N with same assumptions?

As outlined above, you can make three different assumptions.
  1. Uncertain CV → n = 28
  2. Uncertain T/R-ratio → n = 44
  3. Uncertain CV and uncertain T/R-ratio → n = 48
As always with Bayesian methods, the Prior is important. Play with my example and change the size of the pilot study (i.e., the value m). The smaller, the larger the sample size of the next. There­fore, small pilot studies are not a good idea. It may sound stupid, but the best for sample size estimation is a failed pivotal study… :-D

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