Bioequivalence and Bioavailability Forum

Assumptions (plural) [Design Issues]

posted by Helmut  – Vienna, Austria, 2024-05-06 17:31 (259 d 13:12 ago) – Posting: # 23987
Views: 2,587

Hi Achievwin,

❝ How come we have three different N with same assumptions?

As outlined above, you can make three different assumptions.

1. Uncertain CV → n = 28
   
2. Uncertain T/R-ratio → n = 44
   
3. Uncertain CV and uncertain T/R-ratio → n = 48

As always with Bayesian methods, the Prior is important. Play with my example and change the size of the pilot study (i.e., the value m). The smaller, the larger the sample size of the next. There­fore, small pilot studies are not a good idea. It may sound stupid, but the best for sample size estimation is a failed pivotal study… 

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! 
Helmut Schütz


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Complete thread:

• Probability of Success in BE studies Achievwin 2024-05-03 13:43 [Design Issues] 
  • Probability of Success in BE studies Helmut 2024-05-03 14:15
    • Probability of Success in BE studies Achievwin 2024-05-06 14:49
      • Probability of Success in BE studies d_labes 2024-05-06 15:16
        • Probability of Success in BE studies Achievwin 2024-05-06 15:31
      • Assumptions (plural)Helmut 2024-05-06 15:31
        • Assumptions (plural) Achievwin 2024-05-06 15:51