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Hi all,
I am not sure if I presented this question clearly but lets see...
Assuming a drug is highly protein bound (>99%), non-saturable metabolism, and linear clearance, and shows non-linear PK (AUC increases less than proportional) at high doses due to saturated protein binding. If one creates a salt form of this drug such that the rate of absorption is increased (faster Tmax) but bioequivalent to the non-salt form in terms of Cmax and AUC, would the salt form drug show nonlinear PK at a lower dose than the non-salt form?
Thx
J
I am not sure if I presented this question clearly but lets see...
Assuming a drug is highly protein bound (>99%), non-saturable metabolism, and linear clearance, and shows non-linear PK (AUC increases less than proportional) at high doses due to saturated protein binding. If one creates a salt form of this drug such that the rate of absorption is increased (faster Tmax) but bioequivalent to the non-salt form in terms of Cmax and AUC, would the salt form drug show nonlinear PK at a lower dose than the non-salt form?
Thx
J
Complete thread:
- Question about rate of absorptionjag009 2024-03-25 14:33 [PK / PD]
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- Question about rate of absorption dshah 2024-03-26 17:19
Ing. Helmut Schütz