Question about rate of absorption [PK / PD]

posted by jag009  – NJ, 2024-03-25 15:33 (18 d 00:18 ago) – Posting: # 23922
Views: 342

(edited by on 2024-03-25 15:52)

Hi all,

I am not sure if I presented this question clearly but lets see...

Assuming a drug is highly protein bound (>99%), non-saturable metabolism, and linear clearance, and shows non-linear PK (AUC increases less than proportional) at high doses due to saturated protein binding. If one creates a salt form of this drug such that the rate of absorption is increased (faster Tmax) but bioequivalent to the non-salt form in terms of Cmax and AUC, would the salt form drug show nonlinear PK at a lower dose than the non-salt form?

Thx
J

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