AUC in steady state [Design Issues]

posted by Helmut Homepage – Vienna, Austria, 2024-01-27 23:01 (28 d 17:10 ago) – Posting: # 23842
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Hi Divyen,

❝ So you are asking for protocol preparation consideration. The study is in healthy volunteers- so I believe that AUC0-t/AUC0-inf>=0.8 also needs to be followed, so consider sampling accordingly.

Here you err. Neither AUC0–t nor AUC0– are PK metrics of the extent of absorption in steady state.

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