Bioequivalence and Bioavailability Forum

Calculation of intra-subject CVs in replicate design [General Sta­tis­tics]

posted by Sathya – India, 2008-09-20 10:17 (5869 d 19:59 ago) – Posting: # 2380
Views: 15,677

Hello d_labes,

This is Sathya Again.

Now I am trying to precede 4 period, 2 treatment, and 4 sequence studies
(by using the dataset from the link given by you)

SAS Code – Proc Mixed : forum_entry.php?id=1589
Intra_CV Calculation : forum_entry.php?id=1652
Inter_Cv Calculation : forum_entry.php?id=1654

The above links are my major reference for this study.

Further it is defined (subject-by-formulation interaction variance)

sig_D2=G (1, 1) +G (2, 2)-2*G (1, 2)
      =sig_BT2+sig_BR2-2*rho*sig_BT*sig_BR

How can I find rho by using SAS?
And how can I get G matrix in SAS? I tried with G and Gcorr. But I am unable to get
G (1, 1), G (2, 2) and G (1, 2).

I got the following result for G and G CORR

Estimated G Correlation Matrix
Row     Effect  subj    trt     Col1    Col2
1       trt     1       1       1.0000  1.0000
2       trt     1       2       1.0000  1.0000

Labes,

I already said that, I am a beginner. So please help me in documentation too.

What are things I have to submit to the client company generally if BA/BE studies was given to us?

What are the calculations or parameter must be in SAS report for BA/BE?

If once replicate design will give to us for BA/BE study Whether We has to do PBE/ IBE or it depends upon the client requirement? What else the document I have to submit?

Please give me clarity.

Complete thread:

• Calculation of intra-subject CVs in replicate design Dr Andrew Leary 2007-11-20 14:50 [General Sta­tis­tics] 
  • Calculation of intra-subject CVs in replicate design Helmut 2007-11-20 16:27
    • Calculation of intra-subject CVs in replicate design Dr Andrew Leary 2007-11-20 16:46
  • Calculation of intra-subject CVs in replicate design Dr Andrew Leary 2007-12-05 16:35
    • Calculation of intra-subject CVs in replicate design ddubins 2008-03-01 19:28
      • Data set? Helmut 2008-03-02 13:01
      • Calculation of intra-subject CVs in replicate design d_labes 2008-03-03 12:05
        • Calculation of intra-subject CVs in replicate designSathya 2008-09-20 08:17
          • G matrix in SAS Proc Mixed d_labes 2008-09-22 11:35
            • Wordplay :-) Helmut 2008-09-22 11:47
            • G matrix in SAS Proc Mixed Sathya 2008-09-24 11:02
              • G matrix in SAS Proc Mixed d_labes 2008-09-24 12:46
                • G matrix in SAS Proc Mixed Sathya 2008-09-25 06:02