Bioequivalence and Bioavailability Forum

Hi all,

I have a question. What if my NCA calculated half-life of a drug is significantly longer than the literature reported half-life which is well established (and I have old study data to back up the literature half-life as well). The newly calculated half-life is longer because I sampled longer than usual and the bioanalytical method has a much lower BLQ. Note that the elimination phase also has a biphasic appearance. Since the data is the data, I assume there is nothing that I would need to do other than writing something to discuss why the my calculated half-life is longer?

FYI, i just let Phoenix to pick the timepoints itself to calculate the half-life. Of course I can override and select the timepoint as well but then the R2 might not be optimal.

Thx

Jag